Coreg and its Uses Generic Coreg is an alpha- and nonselective beta-blocker used alone or in combination with other medications to treat high blood pressure. Generic Coreg is used in combination with other medications to treat heart failure. Generic Coreg is also used after a heart attack to improve chance of survival.
Generic Coreg works by relaxing the blood vessels so your heart does not have to pump as hard.
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Coreg Mechanism Coreg Working
Beta-blockers block beta-receptors in the heart, lungs and other organs of the body. Blocking these receptors prevents the action of two chemicals called noradrenaline and adrenaline that occur naturally in the body. These are often referred to as the 'fight or flight' chemicals, as they are responsible for the body's reaction to stressful situations.
Generic Coreg mainly blocks beta-receptors in the heart, which causes the heart to beat more slowly and with less force. This means that the heart uses less energy and so requires less oxygen from the blood. The pain of angina is caused by not enough oxygen reaching the heart when it's workload is increased, e.g. during exercise. Coreg prevents this pain by decreasing the oxygen demand of the heart, so that it always has a sufficient supply.
Due to the heart beating more slowly and with less force, the pressure at which blood is pumped out of the heart to the rest of the body is reduced. This is one way in which Generic Coreg reduces blood pressure.
Generic Coreg also blocks receptors called alpha-receptors that are present on the walls of blood vessels. Blocking these receptors causes the blood vessels to widen, which means that there is more space and less resistance in the blood vessels. This is another mechanism by which the pressure in the blood vessels is lowered.
The widened blood vessels also allow more blood to reach the heart, which is another way in which Generic Coreg prevents the pain of angina.
Overall, Generic Coreg decreases the effort required by the heart to pump blood around the body and so can also be used to treat chronic heart failure, where the pumping action of the heart has become less effective.
Because Generic Coreg widens the blood vessels and maintains the blood flow to the extremities, it rarely causes the cold extremities (hands and feet) that can occur in people taking other beta-blockers.
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Coreg Dosage Missed Dose of Coreg
Take the missed dose of Coreg as soon as you remember. If it is almost time for the next dose, however, skip the missed dose of Coreg and only take the next regularly scheduled dose. Do not take a double dose of Coreg.
Excess Dose of Coreg
Generic Coreg in excess dose may show symptoms such as a slow heartbeat, fainting, dizziness, weakness, confusion, seizures, nausea, and vomiting.
Conditions for Storage of Coreg
Store Coreg at room temperature from moisture and heat.
Potencies of Coreg
Coreg Tablets : Coreg 3.125 mg, Coreg 6.25 mg, Coreg 12.5 mg & Coreg 25 mg
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Food and Drug Interactions with Coreg
In people with diabetes, Generic Coreg can prolong the lowering of blood sugar (hypoglycaemia) caused by insulin or other antidiabetic medicines. Individuals should monitor their blood sugar, as Coreg can also mask the signs of hypoglycaemia.
- Generic Coreg may increase the blood levels of the following medicines:
- The blood levels of these medicines should be monitored if they are taken with Coreg.
- If Generic Coreg is taken with digoxin or diltiazem there may be an increased risk of slow heart rate.
- If Generic Coreg is taken with verapamil the risk of slow heart rate and heart block may be increased.
- If Generic Coreg is taken with medicines for abnormal heart rhythms, such as amiodarone or disopyramide, there may be an increased risk of slow heart rate or other adverse effects on the heart.
- Antiarrhythmic medicines, verapamil and diltiazem should not be given intravenously (injected into a vein) to people taking Coreg.
- If Coreg is taken with nifedepine and possibly other calcium channel blockers, the risk of a large fall in blood pressure and heart failure may be increased.
- The increase in blood pressure that occurs when the medicine clonidine is stopped may be worsened if Coreg is being taken at the same time. Coreg should be stopped several days before slowly withdrawing the clonidine.
- Non-steroidal anti-inflammatory drugs (NSAIDs) such as indometacin may reduce the blood pressure lowering effects of Coreg.
- Care should be taken when adrenaline is given with Coreg, as this combination may cause severe high blood pressure and slow heart rate.
- Rifampicin increases the removal of this medicine from the body, which may result in decreased blood levels of Coreg.
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Contraindications with Coreg
Coreg is contraindicated in the following:
- A problem common in the elderly, related to poor control of the working of the heart (sick sinus syndrome)
- Chronic obstructive pulmonary disease (COPD)
- Decreased liver function
- Failure of the electrical impulse that causes the heart to beat to leave the pacemaker of the heart, resulting in decreased heart function (sino-atrial heart block)
- Failure of the heart to maintain adequate circulation of blood (cardiogenic shock)
- History of asthma
- History of breathing difficulties due to a narrowing of the airways (bronchospasm)
- Increased acid levels in the blood (metabolic acidosis)
- Marked fluid retention requiring treatment with intravenous heart medicines (inotropes, e.g. digoxin)
- Serious defect in the heart's electrical message pathways (2nd or 3rd degree heart block), unless an artificial pacemaker is fitted
- Slow heart rate of less than 50 beats per minute (bradycardia)
- Tumor of the adrenal gland (phaeochromocytoma), unless this is first treated with an alpha-blocker medicine
- Very low blood pressure (severe hypotension)
- Allergy to any of its ingredients
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Precautions with Coreg
Coreg should be used with caution in:
- A severe form of angina pectoris, not caused by exertion (Prinzmetal's angina)
- Decreased kidney function
- Disease involving the blood vessels (vascular disease)
- History of psoriasis associated with beta-blocker treatment
- History of serious allergies
- Narrowing of the blood vessels in the hands, causing numb and painful fingers (Raynaud's disease)
- People undergoing therapy to decrease allergy (desensitisation therapy)
- Tumor of the adrenal gland (phaeochromocytoma)
- Pregnancy and Breast-feeding
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Adverse effects with Coreg
The adverse effects associated with Coreg are:
- Disturbed sleep
- Disturbances of the gut such as diarrhea, constipation, nausea, vomiting or abdominal pain
- Weight gain
- Visual disturbances
- Blockade of the electrical pathways which control the pumping action of the heart (heart block)
- Increased blood cholesterol level
- Excessive fluid retention in the body tissues, resulting in swelling (oedema)
- Slow heart rate (bradycardia)
- A drop in blood pressure that occurs when going from lying down to sitting or standing, which
- sults in dizziness and lightheadedness (postural hypotension)
- Weakness or loss of strength (asthenia)
- Depressed mood
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