Pravachol and its Uses
Generic Pravachol is used with diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and certain fatty substances in the blood.
Generic Pravachol is in a class of medications called HMG-CoA reductase inhibitors (statins).
Generic Pravachol blocks the body's ability to make cholesterol. Buildup of cholesterol and fats along the walls of the blood vessels (a process known as atherosclerosis) decreases blood flow and, therefore, the oxygen supply to the heart, brain, and other parts of the body. Lowering blood levels of cholesterol and fats may help to prevent heart disease, angina (chest pain), strokes, and heart attacks.
Generic Pravachol has also been shown to reduce illness and death from heart disease and stroke in people who have already had a heart attack or unstable angina. In these cases Generic Pravachol is beneficial even for people whose cholesterol levels are normal or only slightly raised.
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Pravachol Mechanism Pravachol Working
There are two types of cholesterol in the blood; a 'bad' sort called low-density lipoprotein (LDL) and a 'good' sort called high-density lipoprotein (HDL). LDL is deposited in the arteries and increases the risk of heart disease by clogging and narrowing the arteries, while HDL actually protects the arteries against this.
Generic Pravachol decreases the production of LDL cholesterol by blocking the action of the enzyme in the liver (called HMG-CoA reductase) that is responsible for its production. This decreases the amount of cholesterol in the liver cells, causing them to take up LDL cholesterol from the blood. The decreased cholesterol production and increased removal of LDL cholesterol from the blood ultimately results in lowered blood cholesterol levels.
Generic Pravachol also causes a small decrease in the production of other 'bad fats' in the blood called triglycerides, and a small increase in the level of HDL cholesterol. This results in lowered levels of 'bad fats' and raised levels of 'good fats' in the blood.
As the body produces most cholesterol at night, Pravachol is more effective if taken at night.
Generic Pravachol is prescribed to lower high blood levels of cholesterol (primary hypercholesterolaemia) and other fats (mixed dyslipidaemia) if these cannot be lowered by diet and exercise alone. However, it is important to continue to follow a cholesterol-lowering diet and exercise regime while taking Pravachol.
Lowering cholesterol levels reduces the risk of cholesterol being deposited in the blood vessels. This process is known as atherosclerosis, or hardening of the arteries. If it occurs in the major blood vessels of the heart it can reduce the blood and oxygen supply to the heart, causing angina. It can ultimately block the arteries supplying blood and oxygen to the heart, causing a heart attack (myocardial infarction). Generic Pravachol therefore has an important role in preventing illness and death from heart disease.
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Missed Dose of Pravachol
Take the missed dose of Pravachol as soon as you remember. However, if it is almost time for your next dose, skip the missed dose of Pravachol and take only your next regularly scheduled dose. Do not take a double dose of Pravachol.
Excess Dose of Pravachol
Generic Pravachol in excess dose may show symptoms such as nausea, diarrhea, stomach distress, and indigestion.
Conditions for Storage of Pravachol
Store Pravachol at room temperature away from moisture and heat.
Potencies of Pravachol
Pravachol Tablets pravachol 10 mg, pravachol 20 mg, pravachol 40 mg & pravachol 80 mg
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Food and Drug Interactions with Pravachol
- There may be an increased risk of side effects on the muscles (myopathy) if Generic Pravachol is taken with any of the following medicines:
- fibrates for lowering cholesterol, e.g. bezafibrate, gemfibrozil (fibrate medicines should not normally be used in combination with pravastatin)
- nicotinic acid
- Cholestyramine and colestipol reduce the absorption of Pravachol from the gut. If either of these medicines are being used in combination with Pravachol, the Pravachol dose should be taken either one hour before, or at least 4 hours after the cholestyramine/colestipol dose to prevent this happening.
- The blood level of Pravachol may be increased by the antibiotics clarithromycin or erythromycin.
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Contraindications with Pravachol
Pravachol is contraindicated in the following
- Active liver disease
- People with unexplained raised results in liver function tests
- Allergy to one or any of its ingredients
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Precautions with Pravachol
Pravachol should be used with caution in
- Decreased kidney function
- History of liver disease
- History of heavy alcohol consumption
- History of muscular side effects during previous treatment with a statin or fibrate medicine
- Personal or family history of hereditary muscle disorders
- People aged over 70 years
- Pre-pubescent children
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Adverse effects with Pravachol
The adverse effects associated with Pravachol are
- Visual disturbances
- Disturbances of the gut such as indigestion, nausea and vomiting, diarrhea, constipation, abdominal pain, flatulence
- Skin reactions such as rash and itch
- Increased urination
- Sexual problems
- Pain in the muscles or joints (myalgia or arthralgia)
- Muscle weakness
- Muscle cramps
- Alteration in results of liver function tests
- Pins and needles (paraesthesia)
- Liver disorders
- Muscle breakdown (rhabdomyolysis)
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