Vasotec and its uses
Generic Vasotec is an angiotensin converting enzyme (ACE) inhibitor used to treat high blood pressure. Vasotec may also be used to treat congestive heart disease or to decrease the risk of developing heart failure in some patients with a certain type of heart problem (left ventricular dysfunction).
Generic Vasotec is used alone or in combination with other medications to treat high blood pressure. Generic Vasotec is also used in combination with other medications to treat heart failure.
Generic Vasotec works by decreasing certain chemicals that tighten the blood vessels, so blood flows more smoothly and the heart can pump blood more efficiently.
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Vasotec Mechanism Vasotec Working
ACE inhibitors work by blocking the action of a compound in the body called angiotensin-converting enzyme (ACE). Normally ACE produces another compound called angiotensin II, as part of the body's natural control of blood pressure. Angiotensin II has two actions. Firstly, it causes blood vessels to constrict and narrow, and secondly, it reduces the production of urine by the kidneys. Both these actions increase the pressure within the blood vessels.
As Generic Vasotec blocks the action of ACE, it reduces the production of angiotensin II. This means that the blood vessels are allowed to relax and widen and more urine is produced by the kidneys. The overall effect of this is a drop in blood pressure. Generic Vasotec is therefore be used to treat high blood pressure.
The reduced pressure within the blood vessels means that the heart doesn't have to work as hard to pump the blood around the body. Generic Vasotec therefore reduces the workload of the heart and can be used to improve the symptoms of heart failure, where the heart does not pump efficiently. It can also be used to prevent the development of heart failure in people whose heart is functioning poorly but who don't yet have any symptoms of this. Generic Vasotec is usually used in combination with a diuretic medicine to treat heart failure.
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Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of Vasotec.
Excess Dose of Vasotec
Vasotec in excess may show symptoms such as extreme dizziness, weakness, fainting, and fatigue.
Conditions for storage of Vasotec
Store Vasotec at room temperature away from moisture and heat.
Potencies of Vasotec
Vasotec Tablets: Vasotec 2.5 mg, Vasotec 5 mg & Vasotec 10 mg
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Food and Drug interactions with Vasotec
- People who are taking high doses of diuretic medicines such as frusemide may experience a large drop in blood pressure when this medicine is first started. To avoid this your doctor will, where possible, reduce or stop your diuretic dose for 2 to 3 days before Generic Vasotec is started. People who are taking a diuretic medicine in combination with this one should have regular blood tests to monitor their kidney function and blood potassium levels.
- There is an increased risk of a raised blood potassium level (hyperkalaemia) if Generic Vasotec is taken in combination with any of the following:
- potassium-sparing diuretics, e.g. spironolactone, triamterene, amiloride
- potassium supplements
- potassium-containing salt substitutes
- These should only be used with Vasotec if blood potassium levels are frequently monitored.
- If Generic Vasotec is taken in combination with other medicines that decrease blood pressure, the effects on blood pressure may be additive. Tell your doctor if you feel dizzy or lightheaded after starting treatment with Vasotec, as this could indicate that your blood pressure has dropped too low and the doses of your medicines may need adjusting.
- Generic Vasotec reduces the ability of the body to remove the medicine lithium. As this increases the risk of side effects, this medicine is not usually recommended for people taking lithium. If this medicine is used with lithium, lithium blood levels should be carefully monitored.
- Non-steroidal anti-inflammatory drugs (NSAIDs) e.g. aspirin (doses of 300 mg or higher), indometacin and ibuprofen, may reduce the effect of Vasotec on lowering blood pressure. They may also increase the risk of kidney problems or raised blood potassium levels.
- Generic Vasotec may enhance the blood sugar lowering effect of medicines used to treat diabetes, e.g. insulin or oral antidiabetic medicines. This has happened occasionally and unpredictably and may result in very low blood sugar levels (hypoglycaemia). People with diabetes should therefore carefully monitor their blood sugar while taking Vasotec.
- If Vasotec is taken in combination with ciclosporin there may be an increased risk of side effects on the kidneys.
- There may be an increased risk of a drop in white blood cell counts if Vasotec is used in combination with the following:
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Contraindications with Vasotec
Vasotec is contraindicated in:
- Any condition in which there is obstruction to the pumping of blood out of the heart (outflow tract obstruction)
- Failure of the heart to maintain adequate circulation of blood (cardiogenic shock)
- Hereditary angioedema (angioneurotic oedema)
- History of swelling of the lips, face or tongue (angioedema) caused by an ACE inhibitor
- History of swelling of the lips, face or tongue with no known cause (idiopathic angioedema)
- Kidney failure requiring a certain type of haemodialysis (high-flux membrane)
- People with narrowing of both the arteries that supply blood to the kidneys, or narrowing of one artery in people with only one working kidney (renal artery stenosis)
- Pregnancy: When used during the second and third trimesters of pregnancy, Vasotec can cause injury and even death to the developing baby. Do not take Vasotec if you are pregnant or could become pregnant during treatment. Do not use Vasotec without first talking to your doctor if you are breast-feeding a baby.
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Precautions with Vasotec
Vasotec is to used with precaution in:
- Decreased fluid volume in the body, e.g. due to diuretic therapy, low salt diet, kidney dialysis, diarrhea, vomiting, dehydration
- Decreased kidney function
- Disease of the blood vessels in and around the brain (cerebrovascular disease)
- Diseases affecting connective tissue, e.g. scleroderma, systemic lupus erythematosus, rheumatoid arthritis (collagen vascular diseases)
- Elderly people
- Heart disease caused by inadequate blood flow to the heart (ischaemic heart disease)
- Heart disease characterized by thickening of the internal heart muscle and a blockage inside the heart (hypertrophic obstructive cardiomyopathy)
- High blood pressure caused by compression or blockage of the arteries that carry blood to the kidneys (renovascular hypertension)
- History of swelling of the lips, face or tongue (angioedema)
- Narrowing of one of the valves in the heart (mitral valve stenosis)
- Narrowing of the main artery of the body (aortic stenosis)
- People receiving therapy to remove certain types of fat from the blood using a machine (LDL apheresis)
- People undergoing therapy to decrease allergy to bee or wasp stings (desensitization).
- Severe heart failure
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Adverse effects with Vasotec
The adverse effects with Vasotec include:
- Blurred vision
- Muscle cramps
- High blood potassium level (hyperkalaemia)
- Alteration in taste
- Difficulty in breathing (dyspnoea) A drop in blood pressure that occurs when going from lying down
- to sitting or standing, which results in dizziness and lightheadedness (postural hypotension)
- Weakness or loss of strength (asthenia)
- Decreased kidney function
- Chest pain
- Increased heart rate (tachycardia)
- Disturbances in the normal levels of blood cells in the blood
- Dry cough
- Disturbances of the gut such as diarrhea, constipation, nausea, vomiting or abdominal pain
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