I. Clomid Fact File
Clomid is manufactured by .
Aventis is now part of the Sanofi-Aventis Group. The Sanofi-Aventis
Group is the world's 3rd largest pharmaceutical company, ranking
number 1 in Europe. Backed by a world-class R&D organization,
Sanofi-Aventis is developing leading positions in seven major therapeutic
areas: cardiovascular disease, thrombosis, oncology, diabetes,
central nervous system, internal medicine, and vaccines.
II Clomid Medication:
Clomid medication is an ovulation inducer. Clomid medication (Clomiphene citrate) was first synthesized in 1956 and introduced for clinical trials in 1960. Since then, Generic Clomid has been widely used as a "first line" treatment to induce and regulate ovulation.
Information on Ovulation: Ovulation
is when one or more eggs are released from the ovary and is the
fertile time of your menstrual cycle.
Each month, many eggs mature inside the ovary.
The largest is expelled into the pelvic cavity and swept into the
Fallopian tube. Which ovary releases the egg is fairly arbitrary.
Ovulation does not necessarily rotate between ovaries
FSH from the pituitary causes some of the follicles in the ovary to develop and to make oestrogen.
As more and more FSH reaches the ovaries, the follicles make increasing amounts of oestrogen and move towards the surface of the ovary
One of the follictes reaches the surface and presses on the outer skin of the ovary, forming a bubble.
When a girl is making enough oestrogen, the pituitary slows down its production of FSH and makes LH. The LH travels to the ovary, causing the follicle to burst and release its tiny ovum.
What is the menstrual cycle?
Information about menstrual cycle : The menstrual
cycle varies from one woman to another woman; it first
begins when a girl becomes sexually mature at puberty. The majority
of women will have a cycle that lasts between 25-35 days, with the
average being 28 days, but this can be longer or shorter. The first
day of bleeding is counted as the beginning of your cycle (day 1).
Your menstrual cycle is then the number of days
before your next period starts (the first day of bleeding). The
period can last anything from 3 to 10 days.
What happens during the menstrual cycle?
cycle is a complicated process involving many different hormones,
women's sex organs and the brain. The activity
of a woman's sexual organs, including their development
is under the control of a small gland at the base of the brain,
called the pituitary gland
Two of the most important hormones of the pituitary gland are
Follicle Stimulating Hormone (F.S.H.) and Luteinising Hormone (L.H.).
A woman has 2 ovaries in her reproductive system, each ovaries stores
thousands of follicles, within these follicles are the immature
eggs. More than one follicle may start to develop at a time, but
usually only one reaches maturity each month.
At the start of each menstrual cycle the pituitary gland releases F.S.H. which makes the immature eggs (follicles) grow (this is why F.S.H. gets it name). While the follicle is developing, the cells around the egg produce the female hormone - oestrogen. Each month oestrogen causes the lining of the uterus to grow and prepares the lining of the uterus (womb) to receive the fertilized egg.
When the follicle has reached a certain size and
development, the rising level of oestrogen in the
blood, signal to the pituitary gland that the ovary
is ready to release the egg. The pituitary gland then sends out
a high level of the hormone L.H. (this is commonly
known as 'the L.H. surge') and this signals the ovary to release
the egg (ovulation).
The follicle bursts and the egg leaves the ovary
and travels through one of the fallopian tubes to the uterus. The
cluster of cells, which formed the follicle, now called a corpus
luteum remains in the ovary and starts to produce
the female hormone - progesterone.
When woman has sexual intercourse with a man at
this time and his sperm fertilizes the egg, the
woman becomes pregnant. The fertilized egg attaches
to the uterus and the corpus luteum keeps producing all the progesterone
needed, to keep the egg implanted and growing. Progesterone
also blocks the release of more hormones (L.H. and F.S.H.) from
the pituitary gland so that further ovulation
does not occur during pregnancy If after a few
days, no egg is implanted the corpus luteum stops producing hormones
and gets reabsorbed in the ovary. The levels of
progesterone and oestrogen fall and the lining
of the uterus starts to break up. The unfertilized
egg and the lining of the uterus are released through
the vagina as your 'Period' (this process is also
called menstruation). The cycle then starts all
A summary of the hormones:
Follicle Stimulating Hormone (F.S.H.)
Follicle Stimulating Hormone ( F.S.H.) is produced by the pituitary gland. F.S.H. operates with L.H. to encourage the development of the small follicles (like tiny blisters) in the ovaries. F.S.H. also stimulates the production of the ovarian hormone oestrogen.
Follicle Stimulating Hormone ( F.S.H.) works with L.H. to regulate the activity of the sex organs in men and women. In men F.S.H is necessary for the development of sperm.
Luteinising Hormone (L.H.)
hormone from the pituitary gland that stimulates
ovulation and the development of the corpus luteum.
In men Luteinising Hormone L.H.
stimulates the cells of the testes, which secrete the male sex
Oestrogen is produced mainly by the ovaries
and is largely responsible for the changes that occur in young women
around puberty (e.g. breast development and hair growth).
Oestrogen helps stimulate the growth of the egg
within the follicle. In USA oestrogen is spelt
Progesterone is produced largly by the corpus luteum in the ovary following ovulation. When progesterone is produced it causes a slight increase in body temperature. It is this rise in temperature that is monitored by women using methods of natural family planning, though this is very
Progesterone prepares the lining of the uterus to accept a fertilized egg so that the egg can develop. Progesterone also prevents the release of any further eggs until the pregnancy is terminated.
Clomid is typically administered on either days 3-7 or days
5-9 of the menstrual cycle with "day
one" defined as the first day of normal menstrual flow.
Clomid works at the hypothalamus, a small gland at the base
of the brain. Clomid
medication stimulates the production of gonadotropin releasing
hormone, which stimulates the pituitary gland to produce Follicle
Stimulating Hormone (FSH).
FSH stimulates the development of the ovarian follicles, which contain the eggs.
Side Effects Of Ovulation Inducers
effects of Clomid may include: hot flashes, ovarian
enlargement, breast tenderness, nausea, vomiting, visual
and multiple pregnancy.
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